Keekyoung Kim

Assistant Professor

Department of Mechanical and Manufacturing Engineering

PhD - Mechanical Engineering

University of Toronto, 2008

MASc - Mechanical Engineering

University of Calgary, 2004

BEng - Mechanical Engineering

Kyung Hee University, South Korea, 1994

Contact information

Location

Mechanical Engineering Building : MEB405

Courses

Manufacturing and Production Processes (ENMF 417)


Preferred method of communication

Email


Research

Research areas

  • Advanced biomanufacturing
  • Biofabrication
  • 3D Bioprinting
  • Microfluidics and organ-on-a-chip
  • MEMS and bioMEMS
  • Micro- and nano-systems
  • High-throughput screening
  • Biosensors
  • Wearable technology
  • Molecular, cellular and tissue engineering
  • Stem-cell engineering
  • Tissue mechanics
  • Cell mechanics
  • Biomaterials
  • Nanocomposite materials

Research Activities

In recent years, advanced biomanufacturing has emerged as a promising biomedical engineering solution. Unlike conventional biomanufacturing, advanced biomanufacturing builds on groundbreaking discoveries such as 3D additive manufacturing systems, synthetic biology, stem-cell biology, computational modeling, micro- and nano-fabrication, biomaterials, tissue engineering and regenerative medicine. The emergence of this new field offers tremendous opportunities to spur research, education, and industry growth and innovation. Current research in the Advanced Biofabrication Laboratory at the University of Calgary focuses on the development of reliable, flexible cost-effective advanced biomanufacturing processes and systems. This includes stereolithography-based 3D bioprinting and integrated, high-throughput, microfluidic, cell-laden, microgel fabrication. These systems will be used to reliably produce stem-cell organoids, highly complex tissue constructs, and entire organs that can facilitate drug discovery, disease study and therapeutic treatments.


Biography

Dr. Keekyoung Kim joined the University of Calgary in September 2019 as an assistant professor in the Department of Mechanical and Manufacturing Engineering. Previously, he was an assistant professor in the School of Engineering at the University of British Columbia’s Okanagan Campus from July 2013 to June 2019 where he was promoted as an associate professor in July 2019. He obtained his bachelor degree in Mechanical Engineering from Kyung Hee University in South Korea. After graduation, he joined SsangYong Motor Company as a manufacturing engineer for two years and then worked for Korea Aerospace Industries LTD for six years. He moved to Canada to pursue graduate studies and obtained an MSc in Mechanical Engineering from the University of Calgary. He earned his PhD degree in Mechanical Engineering from the University of Toronto, where he specialized in MEMS devices for microscale biomaterial characterization. During his PhD, he was supported by an NSERC PGS D scholarship for three years. He was a Postdoctoral Fellow at Stanford University in Mechanical Engineering and Pediatric Cardiology, where he studied cell mechanical behavior using polymer MEMS devices. Supported by NSERC during his Postdoctoral Fellowship, he joined Brigham and Women's Hospital at Harvard Medical School and the Wyss Institute of Biologically Inspired Engineering at Harvard University as a Research Fellow. There, he worked on micro-scale tissue engineering and high-throughput screening. Currently, Dr. Kim’s research is focused on the development of advanced biomanufacturing platforms to fabricate artificial tissues and organs for regenerative medicine and drug discovery applications, using a variety of cutting-edge technologies including 3D printing, micro/nanotechnology and high-throughput screening.


Publications

Selected journal articles:

P. Ambhorkar, R. H. Rakin, Z. Wang, and K. Kim, “Biofabrication approaches and strategies for engineering heterogenous artificial tissues,” Additive Manufacturing, in revision, 2019.

H. Montazerian, M.G.A. Mohamed, M.M. Montazeri, S. Kheiri, A.S. Milani, K. Kim, and M. Hoorfar, “Gradient porous PDMS scaffolds 3D-mold-printed with minimal surface architectures,” Acta Biomaterialia, 96: 149-160, 2019.

K. Sakthivel, A. O’Brien, K. Kim*, and M. Hoorfar*, “Microfluidics-based fabrication of in vitro co-culture systems: A review of techniques and applications,” Trends in Analytical Chemistry, in press (DOI: 10.1016/j.trac.2019.03.026), 2019. (*co-corresponding authors)

M.G.A. Mohamed, S. Kheiri, S. Islam, H. Kumar, A. Yang, and K. Kim, “An integrated microfluidic flow-focusing platform for on chip fabrication and filtration of cell-laden microgels,” Lab on a Chip, 19(9):1621-1632 , 2019.

M.G.A. Mohamed, H. Kumar, Z. Wang, N. Martin, B. Mills, and K. Kim, “Rapid and inexpensive fabrication of multi-depth microfluidic device using high-resolution LCD stereolithographic 3d printing,” Journal of Manufacturing and Materials Processing, 3 (1):26, 2019

P. Ambhorkar, Z. Wang, H. Ko, S. Lee, K. Koo, K. Kim*, and D. Cho*, “Nanowire-based biosensors: from growth to applications,” Micromachines, 9(12):679, 2018. (*co-corresponding authors)

Z. Wang, H. Kumar, Z. Tian, X. Jin, J. F. Holzman, F. Menard, and K. Kim, "Visible light photoinitiation of cell adhesive gelatin methacryloyl hydrogels for stereolithography 3D bioprinting," ACS Applied Materials and Interfaces, 10, pp.26859−26869, 2018.

Z. Wang, X. Jin, Z. Tian, F. Menard, J. F. Holzman, and K. Kim, "A novel, well-resolved direct laser bioprinting system for rapid cell encapsulation and microwell fabrication," Advanced Healthcare Materials, Vol.7, p.1701249, 2018.

Z. Wang, N. Martin, B. Mills, and K. Kim, "Rapid fabrication of multi-layer microfluidic devices using liquid crystal display-based stereolithograpy 3D printing system ," 3D Printing and Additive Manufacturing, Vol. 4 (3), pp.156-164, 2017.

Z. Wang, Z. Tian, F. Menard, and K. Kim, “Comparative study of gelatin methacrylate hydrogels from different sources for biofabrication applications,” Biofabrication, Vol. 9, p.044101, 2017.

Z. Wang, A. Boddeda, B. Parker, R. Samanipour, S. Ghosh, F. Menard, and K. Kim, "A high resolution mini-microscope system for wireless real-time monitoring ," IEEE Transactions on Biomedical Engineering, Vol. 65 (7), pp.1524 - 1531, 2018.

Z. Wang, R. Samanipour, M. Gamaleldin, K. Sakthivel, and K. Kim, " An automated system for high-throughput generation and optimization of microdroplets ," Biomicrofluidics, Vol. 10, p. 054110, 2016.

B.A. Nestor, E. Samiei, R. Samanipour, A. Gupta, A. Van den Berg, M. Diaz de Leon Derby, Z. Wang, H. Rezaei Nejad, K. Kim, and M. Hoorfar, " Digital microfluidic platform for dielectrophoretic patterning of cells encapsulated in hydrogel droplets, " RSC Advances, Vol. 6, pp. 57409–57416, 2016.

R. Samanipour, Z. Wang, A. Ahmadi, and K. Kim, "Computational and experimental study of microfluidic flow-focusing generation of hydrogel droplets," Journal of Applied Polymer Science, Vol. 133, p.43701, 2016.

B. Hashmi, K. Kim, J. Zerdani, T. Mammoto, J. Feliz, A. Khaddemhosseini, and D.E. Ingber, "A mechanochemical microarray for studying combinatorial effects on embryonic mesenchymal cell differentiation," Advances in Biomedical Engineering Research, published online, DOI: 10.14355/aber.2016.04.001 2016.

Z. Wang, X. Jin, R. Dai, J. F. Holzman, and K. Kim, "An ultrafast hydrogel photocrosslinking method for direct laser bioprinting," RSC Advances, Vol. 6, pp. 21099-21104, 2016.

Z. Wang, S. Lee, K. Koo and K. Kim, "Nanowire sensors for biological and medical applications," IEEE Transactions on NanoBioscience, Vol. 15(3), pp. 186-199, 2016.

R. Dai, Z. Wang, R. Samanipour, K. Koo, and K. Kim, "Adipose-derived stem cells for tissue engineering and regenerative medicine applications," Stem Cells International, published online, DOI: 10.1155/2016/6737345, 2016.

Z. Wang, B. Calpe, J. Zerdani, Y. Lee, J. Oh, H. Bae, A. Khademhosseini, and K. Kim, "High-throughput investigation of endothelial-to-mesenchymal transformation (EndMT) with combinatorial cellular microarrays," Biotechnology and Bioengineering, Vol. 113(7), pp. 1403-1412, 2016.

C. Mandrycky, Z. Wang, K. Kim, and D.-H. Kim, "3D bioprinting for engineering complex tissues," Biotechnology Advances, Vol. 34 (4), pp. 422–434, 2016.

B. Parker*, R. Samanipour*, A. Ahmadi, and K. Kim, “Rapid fabrication of circular channel microfluidic flow-focuing device for hydrogel droplet generation,” Micro and Nano Letters, Vol. 11(1), pp. 41-45, 2016.

Z. Wang, R. Abdulla, B. Parker, R. Samanipour, S. Ghosh and K. Kim, “A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks,” Biofabrication, Vol. 7(4), p. 045009, 2015.


Awards

NSERC Postdoctoral Fellowship (PDF), 2010 – 2012

NSERC Postgraduate Scholarship (PGS-D), 2005 – 2008

University of Toronto Top-up Award, 2005 – 2008

Ontario Graduate Scholarship (Awarded but declined), 2005

University of Toronto Graduate Research Scholarship, 2004 – 2008

University of Toronto Doctoral Open Fellowship, 2004 – 2005

Korean Honor Scholarship, 2004

Alberta Graduate Student Scholarship, 2004

University of Calgary Graduate Travel Award, 2003

University of Calgary Graduate Research Scholarship, 2002 – 2004