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Amir Sanati Nezhad

Faculty Listing

Mechanical and Manufacturing

Amir Sanati Nezhad

Position: 

Assistant Professor

Phone: 
(403) 220-7708
Fax: 
()
Address: 

EEEL 455B

Biography: 

Dr. Sanati-Nezhad' primary research interest involves BioMEMS, Microfluidics, Tissue Engineering, Micro and Nano Technology, and Lab-on-Chip. His research group has focus on development of integrated bioinspired microdevices using microfluidics and tissue engineering approaches for disease modeling, biological systems modeling, and drug discovery. Another research interest of his group is to develop point-of-care devices for testing infectious diseases, and portable tools for detection of plant and food pathogens.

 He is the Principal Investigator of BioMEMS and Bioinspired Microfluidic Laboratory located in the Calgary Centre for Innovative Technology (CCIT). He is an Assistant Professor of Department of Mechanical and Manufacturing Engineering. He has also a joint appointment with the Biomedical Engineering Program and the Centre for Bioengineering Research & Education (CBRE) at the University of Calgary.

 

Research Activities: 

Areas of research

1.  Integrated microdevices for cellular and molecular studies

Cells are influenced mainly by a combination of mechanical, chemical and electrical cues through their surrounding environment. These cues become particularly important when they are externally applied to the cells to conduct the cell response. For instance, how invading cancer cells can be inhibited by the cues to prevent metastasis, how an electrical signal can be externally applied to immune cells at the wound site to treat the wound and how the injured neural cells and axons can be stimulated by external cues for neural regeneration purposes. Our lab is focused on studying the effects of mechanical and chemical cues on cell response at both the single cell and the high-throughput level by developing integrated microfluidic platforms. The major biomechanical parameters include the driving growth or migratory force, the invasive force, the rigidity of the nucleus, the mechanical properties of cell membrane/ cell wall which can be addressed by integrated manipulating systems such as micro-needles, micro-constricts, microcantilevers, and AFM manipulators. The effect of chemical and electrical stimulations on the biomechanics of the cells will also be investigated to find out how the mechanics of the cells can regulate the migratory or growth pattern of the cells or tissues for future therapy applications. The final stage is to employ the mechanical principles to develop theoretical and numerical cell models in order to predict the behavior of various cells in response to mechanical and chemical cues while the model is supported by the experimental data.

 2. Biomimetic tissue models for disease modeling and drug discovery applications

We intend to combine micro/nano technology and tissue engineering approaches to make organ-on-chip platforms with the applications in disease modeling, drug discovery, pharmacology and tissue engineering. Our lab mainly models those organs that the mechanical stimulation plays a key role on their performance such as innervated or vascularized tissues in the peripheral or central nervous system such as knee, shoulder, cartilage, bone, elbow, spinal cord and brain tissues. We develop physiologically relevant innervated and vascular tissues through integrating multilayer microfluidic chips, tissue engineering principles, and integrated biosensors and biophysical sensors. The synthesized 3D biomimetic tissues are further subjected to the chronic and impact mechanical loading in order to develop future healing methods and treatment protocols, particularly in areas where the injury to these tissues produces inflammation. Computational models will also be coupled to the fabricated tissue to develop future predictive models. Achieving this goal would provide a tremendous advantage and reduce the need for numerous animal or human tests and will also have applications in developing therapies for injured tissues. 

 3. Biosensors for Medical Applications

The BioMEMS and Bioinspired Microfluidics (BioM) Laboratory will use the knowledge in microfluidics, micro/nanotechnology, surface chemistry, and cellular/molecular biology to develop innovative sensors and point-of-care microdevices for medical applications with the particular focus on optofluidic and electrochemical sensors for detecting HIV, cancers and emerging deadly and infectious diseases. This technology will also be adapted to develop portable devices for on-site detection of plant and food pathogens.

 Approaches include

Microfluidics, Micro/nano fabrication, Tissue engineering, Biomaterials, Mathematical modeling, Computational modeling

Publications: 

See Dr. Sanati's Website  for the full list of journal publications

Certifications: 

BSc (Isfahan University of Technology) 2002-2006

MSc (AmirKabir University of Technology) 2006-2009

PhD (Concordia University) 2010-2013

PDF (McGill University) 2013-2014

PDF (Harvard Medical School, Harvard-MIT Division of Health Sciences and Technology) 2014-2015