Human Infectious Diseases-On-Chips Bioengineering Collaborative
Advancing organ on chip technology to see, in real time, how human immune cells react to an infection in the body
Bioengineering microvascular capillary chip
Infectious diseases are a major cause of human suffering and death worldwide. To help develop better pharmaceutical treatments and improve patient outcomes, BME researchers are examining the critical interplay between an infection and the human immune response.
UCalgary researchers are creating lung, brain and kidney capillary organ structures using tissue-engineering techniques and microfluidic chip technologies. The work integrates human tissue structures with advanced microscopic imaging to visualize—live and in real time--how the infection and human immune response interact. Being able to see how immune cells react to a pathogen is an important advancement in developing strategies to treat infections.
Dr. Bryan Yipp and his team are using organ on chip technology to see how human immune cells react to an infection in the body
Human neutrophil clusters obstruct flow in a human lung endothelial model in response to a fungus (C. albicans)